Dimethyl Sulfoxide
Apexbio Technology LLC Sephin1 13098-73-2 10mM (in 1mL DMSO)
Sephin1 (CAS 13098-73-2) is a selective inhibitor of PPP1R15A a regulatory subunit of protein phosphatase 1 involved in the regulation of stress-induced eIF2 dephosphorylation Under endoplasmic reticulum (ER) stress phosphorylated eIF2 attenuates protein synthesis preventing accumulation of misfolded proteins By inhibiting PPP1R15A Sephin1 sustains eIF2 phosphorylation extending translational attenuation during ER stress In cell assays Sephin1 selectively disrupts PPP1R15A-PP1c complexes without affecting PPP1R15B-mediated complexes In mouse models harboring misfolded protein mutations (e g MPZ or SOD1) Sephin1 administration mitigates molecular cellular and functional deficits thus relevant for proteostasis-related disease studies
Apexbio Technology LLC Cyclopamine 4449-51-8 10mM (in 1mL DMSO)
Cyclopamine (CAS 4449-51-8) is a naturally occurring steroidal alkaloid that selectively inhibits the Hedgehog (Hh) signaling pathway a conserved cascade involved in cellular proliferation and differentiation In human breast cancer cell lines (MCF-7 and MDA-MB-231) cyclopamine treatment (10 20 M) significantly suppresses proliferation induces cell cycle arrest at G1 phase and reduces invasive capabilities In FXR-bla assays cyclopamine exhibits an EC50 of 10 57 M As an Hh-antagonist it is widely utilized in research examining embryogenesis cancer biology tumor invasiveness and developmental defects
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 10mM (in 1mL DMSO), CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Apexbio Technology LLC Reparixin 266359-83-5 10mM (in 1mL DMSO)
Reparixin (CAS 266359-83-5) is a noncompetitive allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 which are seven-transmembrane G-protein coupled receptors involved notably in acute inflammatory responses Reparixin specifically disrupts CXCR1/2-mediated neutrophil recruitment and migration without affecting other receptor pathways In murine ischemia-reperfusion injury models Reparixin administration significantly inhibits neutrophil influx and associated inflammation-related tissue damage Thus Reparixin serves as a valuable research tool for investigating CXCR-dependent inflammatory mechanisms and evaluating therapeutic potentials in conditions such as acute lung injury and spinal cord damage
Apexbio Technology LLC Hyoscyamine(Synonyms: Levsin, Anaspaz, Daturine, Atropine sulfate (isomer), Hyoscyamin, Tropine tropate, (-)-Hyoscyamine), 10mM (in 1mL DMSO), CAS: 101-31-5.
Hyoscyamine (CAS 101-31-5) is a small molecule antagonist targeting acetylcholine receptors (AChR) Acting via inhibition of cholinergic signaling it exhibits a potent inhibitory activity with an IC50 of approximately 7 5 nM By blocking AChRs hyoscyamine modulates neurotransmission pathways involved in autonomic regulation Research applications include studies exploring cholinergic function investigations into parasympathetic nervous system disorders and testing therapeutic strategies involving ACh modulation
Apexbio Technology LLC Tolcapone 134308-13-7 10mM (in 1mL DMSO)
Tolcapone (CAS 134308-13-7) is an orally bioavailable reversible small-molecule inhibitor targeting catechol-O-methyltransferase (COMT) Acting through competitive inhibition tolcapone structurally incorporates a catechol moiety with electron-withdrawing substituents facilitating anionic formation that binds potently to COMT s catalytic site (reported IC50 of approximately 36 nM in rat liver assays) By competitively occupying this active site tolcapone prevents the enzymatic methylation of endogenous catechols such as levodopa thus prolonging levodopa s bioavailability Tolcapone is primarily investigated as adjunctive therapeutic agent in Parkinson s disease research enabling reduced levodopa dosage while enhancing symptomatic control
Apexbio Technology LLC GW501516 317318-70-0 10mM (in 1mL DMSO)
GW501516 is a subtype-selective synthetic agonist targeting peroxisome proliferator-activated receptor delta (PPAR ) exhibiting a Ki value of approximately 1 1 nM PPAR widely expressed in various tissues mediates cholesterol metabolism and interacts with retinoid X receptor (RXR) In cellular reporter assays utilizing a GAL4-driven system GW501516 activates PPAR -dependent transcription with an EC50 value close to 1 2 nM and demonstrates roughly 1000-fold greater selectivity toward PPAR compared to other PPAR isoforms Experimental studies in primate models of metabolic disease have shown GW501516 promotes HDL-cholesterol elevation reduces fasting triglycerides modifies LDL/VLDL particle profiles to larger forms enhances cholesterol efflux via increasing ABCA1 expression and partially reduces hyperinsulinemia without adverse effects on glucose handling GW501516 serves as a research tool for exploring the mechanisms and functions of PPAR activation in metabolic regulation
Cayman Chemical DMSO asy Reagent 1mL
A DPP-9 inhibitor (IC50 0.0034 UM) selective for DDP-9 over DPP-8 DPP-4 DPP-2 FAP and prolyl endopeptidase (IC50s 0.6 >10 >5 10 and >10 UM respectively) induces LDH release from THP-1 and HL-60 leukemia cells at 10 UM
Selleck Chemical LLC Trametinib DMSO solvate S4484-100mg
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Medchemexpress LLC Azd0780 10Mm 1Ml Dmso Reconst | HY-148673-10MM DMSO RECON
Azd0780 10Mm 1Ml Dmso Reconst
Apexbio Technology LLC GSK3787 188591-46-0 10mM (in 1mL DMSO)
GSK3787 is an irreversible antagonist targeting peroxisome proliferator-activated receptor beta/delta (PPAR- / ) Structurally it acts through covalent modification by binding specific cysteine residues within the ligand-binding domain of PPAR- / thereby disrupting receptor activation and subsequent co-regulator interactions Due to receptor selectivity GSK3787 preferentially inhibits PPAR- / relative to PPAR- Experimental evidence in rodent models demonstrates that oral administration of GSK3787 counteracts agonist-induced gene expression such as Angptl4 and Adrp by reducing recruitment of activated PPAR- / to target gene promoters indicating potential utility in studying PPAR- / -mediated regulatory pathways related to lipid metabolism and gene transcription in vitro and in vivo
Apexbio Technology LLC (-)-JQ1 1268524-71-5 10mM (in 1mL DMSO)
(-)-JQ1 (CAS 1268524-71-5) is a stereoisomer of ( )-JQ1 designed as a negative control in bromodomain inhibition studies Unlike ( )-JQ1 a competitive BET bromodomain inhibitor known to displace BRD4 fusion oncoproteins from chromatin the (-)-enantiomer shows negligible interaction with tested bromodomains It exhibits minimal inhibitory activity against BRD4(1) with an IC50 of 10 000 nM Due to the lack of significant bromodomain binding (-)-JQ1 serves widely as an appropriate negative control compound in experiments investigating BET protein functions and related signaling
Apexbio Technology LLC Propylthiouracil 51-52-5 10mM (in 1mL DMSO)
Propylthiouracil is a thioureylene derivative characterized by inhibitory effects on thyroid hormone synthesis through targeting thyroid peroxidase (TPO) and type 1 iodothyronine deiodinase (DIO1) Its mechanistic actions involve suppression of TPO activity disrupting iodine oxidation and subsequent thyroid hormone formation as well as inhibition of peripheral thyroid hormone conversion via decreased DIO1 enzymatic activity In biomedical research Propylthiouracil is commonly utilized to investigate molecular pathways underlying hyperthyroid conditions such as Graves disease as well as to experimentally explore metabolic regulation of thyroid hormones
Apexbio Technology LLC Proparacaine HCl 5875-06-9 10mM (in 1mL DMSO)
Proparacaine HCl (CAS 5875-06-9) is a small-molecule antagonist of voltage-gated sodium channels By inhibiting sodium ion entry through these channels Proparacaine HCl effectively suppresses action potential generation and neuronal signaling Assays demonstrate an ED50 value of approximately 3 4 mM Due to its sodium channel inhibition Proparacaine HCl is utilized in scientific research to study neuronal excitability ion channel function and related electrophysiological processes
Apexbio Technology LLC Bexarotene 153559-49-0 10mM (in 1mL DMSO)
Bexarotene is a synthetic selective agonist for retinoid X receptors (RXRs) a subclass of nuclear hormone receptors involved in the regulation of gene transcription Upon binding to RXRs Bexarotene modulates the expression of target genes associated with cell differentiation proliferation and apoptosis Due to this mechanism Bexarotene is commonly employed in research investigating tumor growth inhibition cellular differentiation pathways and apoptosis induction Researchers also frequently utilize this retinoid derivative to elucidate RXR-mediated signaling pathways in oncology and to explore potential therapeutic applications for various malignancies