Dimethyl Sulfoxide
Apexbio Technology LLC SL-327 305350-87-2 10mM (in 1mL DMSO)
SL-327 (CAS 305350-87-2) is a selective inhibitor targeting MEK1 and MEK2 kinases exhibiting IC50 values of 0 18 M and 0 22 M respectively MEK1/2 mediate the phosphorylation and activation of extracellular signal-regulated kinases (ERK) crucial components of the MAPK/ERK signaling pathway SL-327 treatment lowers phosphorylated ERK levels and subsequent activation of transcription factors including CREB Elk-1 and c-Fos influencing gene expression linked to synaptic plasticity In animal models SL-327 modulates drug-induced behaviors and neuronal plasticity processes making it a relevant molecular tool to investigate MAPK/ERK signaling pathways in neuroscience research
Apexbio Technology LLC Topotecan 123948-87-8 10mM (in 1mL DMSO)
Topotecan (CAS 123948-87-8) a semisynthetic derivative of camptothecin functions by selectively inhibiting topoisomerase I This inhibition stabilizes enzyme-DNA cleavage complexes disrupting DNA replication and transcription processes essential for tumor cell proliferation In preclinical studies topotecan demonstrated antitumor activity in mouse models of leukemia (P388) Lewis lung carcinoma B16 melanoma and human colon adenocarcinoma xenograft HT-29 Its toxicity primarily affecting rapidly proliferating tissues such as bone marrow and gastrointestinal epithelium was concentration-dependent and reversible Topotecan is employed extensively as a research tool in oncology studies focusing on DNA-topoisomerase interactions and targeting solid tumor growth
Apexbio Technology LLC MLN120B 783348-36-7 10mM (in 1mL DMSO)
MLN120B (CAS 783348-36-7) is a small molecule inhibitor targeting the beta subunit of I B kinase (IKK ) an enzyme integral to the NF- B signaling pathway IKK mediates phosphorylation and subsequent degradation of the NF- B inhibitor I B thereby activating NF- B-dependent transcription involved in inflammatory and immune responses MLN120B inhibits IKK -catalyzed phosphorylation of I B (IC50 20 M) attenuating NF- B activation in multiple myeloma cell lines (RPMI 8226 INA 6 MM 1S) and reducing inflammation-induced joint damage in animal arthritis models Consequently MLN120B serves as a research tool in studying NF- B signaling-mediated disorders
Apexbio Technology LLC AGN 194310 229961-45-9 10mM (in 1mL DMSO)
AGN 194310 is a pan-retinoic acid receptor (RAR) antagonist with affinity for RAR RAR and RAR It binds these receptors with Kd values of 3 nM 2 nM and 5 nM respectively By competing with RAR agonists AGN 194310 blocks receptor-mediated cellular responses In cell-based assays AGN 194310 inhibits the proliferation and colony formation of prostate carcinoma cell lines (LNCaP PC3 DU-145) induces G1 cell cycle arrest and promotes apoptosis In addition it suppresses agonist-induced differentiation in HL60 cells AGN 194310 serves as a research tool to investigate RAR-driven signaling pathways and tumor cell growth mechanisms particularly in oncology studies examining retinoid receptor functions
Apexbio Technology LLC TAK-242 243984-11-4 10mM (in 1mL DMSO)
TAK-242 (CAS 243984-11-4) also known as resatorvid is a cyclohexene derivative that functions as a selective inhibitor of Toll-like receptor 4 (TLR4) signaling Mechanistically TAK-242 binds specifically to the intracellular domain of TLR4 disrupting its interaction with downstream adaptor proteins and thus suppressing activation of inflammatory signal pathways triggered by lipopolysaccharide (LPS) In vitro TAK-242 inhibits LPS-induced production of nitric oxide TNF- and interleukin-6 in macrophages (IC50 1 1 11 nM) Preclinical animal models indicate its potential usefulness in mitigating inflammatory responses associated with neuropsychiatric conditions triggered by stress
Apexbio Technology LLC PF-3758309 898044-15-0 10mM (in 1mL DMSO)
PF-3758309 (CAS 898044-15-0) is a selective ATP-competitive inhibitor of p21-activated kinase 4 (PAK4) a serine/threonine kinase involved in cytoskeletal reorganization and cellular signaling mediated by Cdc42-GTP and JNK-GTP interactions PF-3758309 inhibits phosphorylation of PAK4 substrates (e g GEF-H1 IC50 1 3 nM) and suppresses PAK4-mediated anchorage-independent growth In xenograft tumor models (HCT116 A549) oral administration of PF-3758309 significantly reduced tumor growth demonstrating its utility in research investigating PAK-dependent oncogenic pathways
Apexbio Technology LLC VS-5584 (SB2343) 1246560-33-7 10mM (in 1mL DMSO)
VS-5584 (SB2343 CAS 1246560-33-7) is a purine-based inhibitor targeting the mammalian target of rapamycin (mTOR) and all class I phosphoinositide 3-kinase (PI3K) isoforms (PI3K PI3K PI3K and PI3K ) It functions through ATP-competitive inhibition displaying IC50 values of 37 16 68 25 and 42 nmol/L against mTOR PI3K PI3K PI3K and PI3K respectively Through inhibition of PI3K and mTORC1/2-mediated substrate phosphorylation VS-5584 modulates the PI3K/mTOR signaling pathway frequently dysregulated in cancers In preclinical tumor xenograft studies VS-5584 has demonstrated dose-dependent inhibition of tumor growth and pathway signaling underscoring its utility in oncology research
Apexbio Technology LLC BKM120 944396-07-0 10mM (in 1mL DMSO)
BKM120 (CAS 944396-07-0) is a potent orally bioavailable inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) specifically targeting the isoforms p110 p110 p110 and p110 with IC50 values of 52 nM 166 nM 262 nM and 116 nM respectively By blocking PI3K activity this molecule suppresses downstream phosphorylation of AKT an important mediator within the PI3K-AKT-mTOR signaling cascade implicated in tumor growth and survival Preclinical studies demonstrate that BKM120 restricts tumor cell proliferation promotes cell cycle arrest at G1 phase and induces apoptosis particularly noted in PTEN-deficient cancer models Thus BKM120 serves as a useful tool for studying PI3K pathway-dependent cancers
Apexbio Technology LLC Acetaminophen 103-90-2 10mM (in 1mL DMSO)
Acetaminophen (paracetamol) is a cyclooxygenase-2 (COX-2) inhibitor widely employed in biomedical studies for investigating analgesic and antipyretic mechanisms Its inhibition of COX-2 enzyme activity occurs with an IC50 of approximately 25 8 M Experimental use includes inducing cellular hepatotoxicity models where acetaminophen exposure triggers glutathione depletion impaired glutathione peroxidase activity and ferroptosis-mediated cell death This makes acetaminophen useful in examining oxidative stress hepatic cell injury and associated cellular response mechanisms in vitro and in animal studies Additionally acetaminophen-mediated toxicity is applicable in screening protective agents or evaluating ferroptosis inhibitors in pharmacological research
Apexbio Technology LLC vinblastine 865-21-4 10mM (in 1mL DMSO)
Vinblastine is a naturally-derived alkaloid isolated from Catharanthus roseus It functions as a microtubule inhibitor by binding specifically to tubulin disrupting microtubule polymerization and thereby arresting mitosis at metaphase Due to this mechanism vinblastine is widely investigated for antitumor activities and is commonly employed in biomedical research to study cell division cytoskeletal dynamics and therapeutic interventions in oncology Vinblastine should be stored under sealed dry and cool conditions to maintain molecular integrity and biological activity
Apexbio Technology LLC Santacruzamate A (CAY10683) 1477949-42-0 10mM (in 1mL DMSO)
Santacruzamate A (CAY10683 CAS 1477949-42-0) is a selective histone deacetylase (HDAC) inhibitor originally identified in the marine cyanobacterium cf Symploca sp Its mechanism of action involves targeting HDAC enzymes particularly demonstrating high selectivity towards HDAC2 (IC 0 112 nM) when compared with HDAC6 (IC 433 nM) and minimal potency against HDAC4 (IC 1 M) In cellular assays Santacruzamate A reduces growth of tumor cell lines such as HCT-116 colon cancer cells (GI 28 M) and HuT-78 cutaneous T-cell lymphoma cells (GI 1 3 M) It is valuable in epigenetics and oncology research for selectively modulating HDAC2 activity
Medchemexpress LLC Ly2090314 1Ml Dmso Reconstitut | HY-16294-1ML DMSO RECONST
Ly2090314 1Ml Dmso Reconstitut
Apexbio Technology LLC MRT67307 HCl 2095432-39-4 10mM (in 1mL DMSO)
MRT67307 HCl (CAS 2095432-39-4) is a small-molecule inhibitor targeting several kinases including TBK1 IKK MARK1-4 NUAK1 ULK1/2 and salt-inducible kinases (SIK1-3) It inhibits TBK1 and IKK to block phosphorylation of IRF3 reducing interferon- synthesis without affecting NF- B activation Additionally MRT67307-mediated SIK inhibition promotes regulatory macrophage differentiation leading to elevated anti-inflammatory cytokines (e g IL-10 IL-1ra) and decreased pro-inflammatory cytokines (IL-6 IL-12 TNF) It is utilized to investigate innate immunity macrophage polarization autophagy and inflammation pathways
Apexbio Technology LLC OTX-015 202590-98-5 10mM (in 1mL DMSO)
OTX-015 (CAS 202590-98-5) is a selective inhibitor of BRD2 BRD3 and BRD4 proteins within the BET (bromodomain and extra-terminal) family involved in transcriptional regulation By disrupting the interaction between these BRD proteins and acetylated histone H4 OTX-015 exhibits inhibitory activity demonstrated by IC50 values between 92 and 112 nM and in vitro EC50 ranging from 10 to 19 nM OTX-015 treatment reduces proliferation (GI50 60 200 nM) induces G1 arrest and promotes apoptosis in various human cancer cell models In xenograft mouse studies of BRD-NUT midline carcinoma orally administered OTX-015 significantly suppresses tumor growth showing potential utility for cancer research