Dimethyl Sulfoxide
Apexbio Technology LLC AZD8931 (Sapitinib) 848942-61-0 10mM (in 1mL DMSO)
AZD8931 (Sapitinib CAS 848942-61-0) is a reversible small-molecule inhibitor that targets EGFR (HER1) HER2 (erbB2) and HER3 (erbB3) with similar potency It suppresses receptor phosphorylation with IC50 values of 4 nM (EGFR) 3 nM (HER2) and 4 nM (HER3) Preclinical studies using HER2-non-amplified inflammatory breast cancer (IBC) cell lines demonstrate reduced tumor cell proliferation and increased apoptosis upon AZD8931 administration In mouse xenograft models AZD8931 alone or combined with paclitaxel significantly delays tumor growth AZD8931 is under clinical evaluation as combination therapy in advanced breast cancer
Apexbio Technology LLC Ulipristal 159811-51-5 10mM (in 1mL DMSO)
Ulipristal is a selective progesterone receptor modulator (SPRM) exhibiting tissue-specific agonist and antagonist activities on progesterone-sensitive targets It functions through competitively binding to the progesterone receptor thereby modulating downstream cellular and physiological responses Ulipristal has been explored in biomedical research primarily for emergency contraception administered within 120 hours following unprotected intercourse Additionally ulipristal demonstrates potential utility in managing benign gynecological disorders such as uterine fibroids (leiomyomas) by mediating apoptosis in myomatous cells and controlling cellular proliferation In vitro studies indicate that ulipristal acetate inhibits progesterone-stimulated acrosome reactions and hyperactivation of human spermatozoa highlighting its potential receptor-mediated modulation of sperm functions
Apexbio Technology LLC AT9283 896466-04-9 10mM (in 1mL DMSO)
AT9283 (CAS 896466-04-9) is a synthetic small-molecule inhibitor developed through fragment-based drug design It inhibits Aurora kinases A and B key components of the serine/threonine kinase family involved in regulating cell division processes as well as targets including Janus kinases (JAKs) BCR-ABL kinase (including the T315I mutant) and Flt-3 With a potent IC50 around 3 nM against Aurora kinases AT9283 exhibits antiproliferative and pro-apoptotic activity in leukemia myeloproliferative diseases solid tumors and B-cell lymphoma models It is utilized primarily in cancer biology research to investigate its therapeutic potential targeting aberrant kinase activity
Apexbio Technology LLC CUDC-101 1012054-59-9 10mM (in 1mL DMSO)
CUDC-101 (CAS 1012054-59-9) is a multitargeted small molecule inhibitor that concurrently targets epidermal growth factor receptor (EGFR) HER2 and class I and II histone deacetylases (HDACs) By inhibiting EGFR and HER2 kinases directly and simultaneously blocking HDAC activity CUDC-101 downregulates multiple oncogenic signaling pathways including those mediated by Akt HER3 and MET Preclinical assessments demonstrate that CUDC-101 inhibits growth of diverse tumor cell lines and xenograft models notably including those resistant to EGFR-targeted agents such as lapatinib and erlotinib These characteristics render CUDC-101 valuable for oncology research and drug resistance studies
Andwin Scientific BDH Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 1L, 6/cs
Formula: (CH₃)₂SO, MW: 78.14 g/mol, Boiling Pt: 189 °C (1013 hPa), Melting Pt: 18.5 °C; BDH Dimethyl Sulfoxide is suitable for general laboratory sse including cytology histology organic synthesis cleaning prep scale synthesis. Packaged In 1-Liter Plastic Bottles, 6 Bottles Per Case. ACS Certified.
Apexbio Technology LLC RO5126766(CH5126766) 946128-88-7 10mM (in 1mL DMSO)
RO5126766 (CH5126766 CAS 946128-88-7) is a dual Raf/MEK inhibitor that targets the RAS/RAF/MEK/ERK signaling pathway involved in cellular proliferation survival and differentiation By inhibiting RAF-dependent MEK1 phosphorylation and subsequent MEK-mediated ERK activation RO5126766 suppresses downstream signaling In vitro kinase assays show IC50 values of 0 0082 0 056 M for MEK1 phosphorylation and 0 16 M for MEK1-induced ERK2 activation Studies in KRAS-mutant cancer cell lines such as HCT116 and NCI-H460 demonstrate that RO5126766 blocks MEK and ERK phosphorylation effectively inducing cell cycle arrest at the G1 stage Thus RO5126766 serves as a valuable research tool for investigating tumor biology driven by MAPK signaling dysregulation
Apexbio Technology LLC RK-33 1070773-09-9 10mM (in 1mL DMSO)
RK-33 is a small molecule inhibitor targeting DDX3 an RNA helicase frequently overexpressed in various cancer types including lung cancer DDX3 overexpression correlates with poorer survival outcomes in lung cancer patients suggesting therapeutic relevance Mechanistically RK-33 inhibits DDX3 enzymatic activity thereby disrupting downstream signaling pathways particularly the -catenin-dependent Wnt signaling axis In vitro studies indicate RK-33 induces cell cycle arrest at G1 phase promotes apoptosis and enhances cellular radiosensitivity in DDX3-high expressing cell lines (e g A549 H1299 H23 and H460 IC50 4 4 8 4 M) In preclinical in vivo testing using a Twist1/KrasG12D mouse lung cancer model combined treatment of RK-33 with radiation resulted in reduced tumor growth compared with radiation alone RK-33 serves as a research tool to investigate DDX3 biology and potential therapeutic strategies for cancers with elevated DDX3 expression
Apexbio Technology LLC Nexturastat A 1403783-31-2 10mM (in 1mL DMSO)
Nexturastat A (CAS 1403783-31-2) is a selective small-molecule inhibitor of histone deacetylase 6 (HDAC6) It displays potent inhibitory activity against HDAC6 with an IC50 of 5 2 nM While predominantly targeting HDAC6 Nexturastat A also exhibits moderate inhibitory effects on other HDAC isoforms (HDAC1-5 and 7-11) at low micromolar concentrations In cell-based studies including mouse B16 melanoma cell lines Nexturastat A has shown antiproliferative properties and induction of apoptosis Due to its selective HDAC6 inhibition Nexturastat A is utilized in cancer research focusing on epigenetic regulation and therapeutic development
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Posaconazole 171228-49-2 10mM (in 1mL DMSO)
Posaconazole a triazole antifungal derivative of itraconazole acts by inhibition of sterol 14 -demethylase involved in fungal ergosterol biosynthesis It binds directly to the enzyme s heme cofactor blocking conversion of lanosterol into downstream sterol intermediates disrupting fungal membrane integrity and cellular function Posaconazole shows inhibitory activity in vitro against Candida albicans strains (IC50 0 007 0 3 g/ml) and Aspergillus species including A fumigatus and A flavus (IC50 0 03 g/ml) It is commonly utilized in biomedical research investigating fungal biology and drug resistance mechanisms
Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles
Apexbio Technology LLC GDC-0449 (Vismodegib) 879085-55-9 10mM (in 1mL DMSO)
GDC-0449 (Vismodegib CAS 879085-55-9) is a small molecule that selectively inhibits the Hedgehog (Hh) signaling pathway by binding to the Smoothened (SMO) receptor thus preventing downstream activation of Hh target genes implicated in cellular proliferation and differentiation This compound emerged from screening small-molecule libraries followed by medicinal chemistry optimization Preclinical evaluation demonstrated antitumor activity in murine models of medulloblastoma and xenograft models derived from human colon and pancreatic cancers Currently GDC-0449 is under investigation for locally advanced and metastatic solid tumors
Apexbio Technology LLC GMX1778 (CHS828) 200484-11-3 10mM (in 1mL DMSO)
GMX1778 (CHS828 CAS 200484-11-3) is a small-molecule inhibitor targeting nicotinamide phosphoribosyltransferase (NAMPT) an enzyme crucial for NAD biosynthesis with a reported Kd value of 120 nM NAD functions as a cofactor essential for enzymatic oxidation-reduction processes and diverse cellular events including metabolism genomic integrity calcium signaling aging and apoptosis In cultured IM-9 cells exposure to GMX1778 substantially decreases NAD and NM levels in a time-dependent manner GMX1778 displays anti-tumor activity preferentially in NAPRT1-deficient cancer models highlighting its potential utility for investigating metabolic vulnerabilities and targeted cancer therapies
Apexbio Technology LLC (+)-Bicuculline 485-49-4 10mM (in 1mL DMSO)
( )-Bicuculline is a competitive antagonist of gamma-aminobutyric acid type A (GABA A) receptors frequently employed as a pharmacological tool to elucidate the functional roles of inhibitory neurotransmission mediated by GABA A By antagonizing GABA binding this compound prevents chloride ion influx leading to reductions in neuronal inhibitory postsynaptic potentials (IPSPs) Additionally ( )-Bicuculline blocks small conductance calcium-activated potassium (SK) channels affecting neuronal excitability and firing patterns It is commonly utilized in electrophysiological studies such as patch-clamp or extracellular recordings to investigate synaptic transmission neuroplasticity mechanisms and epileptic activity models ( )-Bicuculline inhibits GABA A receptors with an IC 50 typically reported in the low micromolar range (approximately 2 5 M)
Sigma Aldrich Fine Chemicals Biosciences CryoSOfreeTM DMSO free Cry
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry compared to the standard use of DMSO for cryopreservation of cell cultures. for more information see here.
